| abstract |
Carbacyclin derivatives of Formula I ##STR1## wherein R 1 is OR 2 , wherein R 2 is hydrogen, alkyl, cycloalkyl, aryl, a heterocyclic residue, or NHR 3 , wherein R 3 is an acid residue or hydrogen; n X is oxygen; n A is --CH 2 --CH 2 --, trans--CH═CH--, or --C.tbd.C--; n W is free or functionally modified hydroxymethylene or free or functionally modified ##STR2## wherein the OH-group can be in the α- or β-position; D is a straight-chain or branched, saturated or unsaturated aliphatic group of 1-10 carbon atoms, which can optionally be substituted by fluorine atoms, 1,2-methylene, 1,1-trimethylene; n E is --C.tbd.C-- or --CR 6 ═CH 7 -- wherein R 6 and R 7 are hydrogen or alkyl of 1-5 carbon atoms; n R 4 is an aliphatic group, cycloalkyl, optionally substituted aryl, or a heterocyclic group; n R 5 is free or functionally modified hydroxy and, n when R 2 is hydrogen, the physiologically compatible salts thereof with bases, have valuable pharmacological properties. |