| abstract |
Carbacyclins of Formula I ##STR1## wherein R 1 is an alkyl, cycloalkyl, aryl, aralkyl, or heterocyclic group, n Y is a keto group or a hydroxymethylene group, n X is a --CH 2 -- group or an oxygen atom, n A is a --CH 2 --CH 2 --, a trans--CH═CH-- or a --C.tbd.C-- group, n W is a hydroxymethylene group or a ##STR2## D is the group ##STR3## a straight-chain or branched, saturated alkylene group or unsaturated alkylene group of up to 5 carbon atoms which can optionally be substituted by 1-2 fluorine atoms, n n is 1, 2 or 3, n E is a direct bond, a --C.tbd.C-- group or a --CR 4 ═CR 5 -- group wherein R 4 is hydrogen or an alkyl group and R 5 is hydrogen, halogen or an alkyl group, n R 2 is an alkyl, cycloalkyl, aryl, or heterocyclic group, and n R 3 is a hydroxy group, n are valuable, e.g., as cytoprotective agents. |