| abstract |
1,4-Dihydro-1-(lower-alkyl)-4-oxo-5(or 6)-R'-7-pyridyl-3-quinolinecarboxylic acids and lower-alkyl esters, where R' is hydrogen, halo, lower-alkyl or lower-alkoxy and pyridyl is unsubstituted or substituted, having antibacterial activity, are prepared by reacting the corresponding 1,4-dihydro-4-oxo-7-pyridyl-3-quinolinecarboxylic acid or lower-alkyl ester with an alkylating agent, e.g., lower-alkyl halide, sulfate or sulfonate, and by other methods. |