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filingDate 1988-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1990-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber EP-0306764-A3
titleOfInvention 4-quinolone-3-carboxylic-acid derivatives and their use as antibacterial agents
abstract A novel series of quinoline-, naphthyridine- and nbenzoxazine-carboxylic acids (I) useful as antibacterial agents nis described. Novel methods for preparing the compounds as nwell as novel intermediates are also described as are methods nfor their formulation and the use thereof in treating nbacterial infections. n nwhere Z is n nwherein one endocyclic double bond may be present between any ntwo consecutive ring positions or two alternating or nnonalternating endocyclic double bonds may be present nin the ring; nwherein n, n′, n‴, and n″″ are each independently 0, n1, or 2; nn″ is 0, 1, 2, or 3; ny is 0 or 1; nx is 0 or 1; nA and B are each independently CH, CH₂, NR₇ nwherein R₇ is hydrogen or R₇ is R₈CO nwherein R₈ is alkyl of from one to ten carbon atoms, narylalkyl, aryl wherein the aryl or alkyl may be nsubstituted by hydroxy, halogen, COOH, or CONHR₉ nwherein R₉ is hydrogen or alkyl of from one to four carbon natoms and when A is NR₇, B can be O or S or when B is nNR₇, A can be absent; n(CR₁₃R₁₄) n‴ wherein R₁₃ and R₁₄ are each nindependently hydrogen or lower alkyl; and nE is hydrogen, alkyl, OR₁₀ wherein R₁₀ is nhydrogen or alkyl, NR₁₁R₁₂ wherein R₁₁ and R₁₂ are neach independently hydrogen, lower alkyl, cycloalkyl nalkylaryl, alkylheteroaryl, alkanoyl, amidine, peptide nurethane, or R₁₁ and R₁₂ when taken together with nthe nitrogen to which they are attached form a ring of nfrom three to six carbon atoms or
priorityDate 1987-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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