| abstract |
A novel series of quinoline-, naphthyridine- and benzoxazine-carboxylic acids (I) useful as antibacterial agents is described. Novel methods for preparing the compounds as well as novel intermediates are also described as are methods for their formulation and the use thereof in treating bacterial infections.n where Z isn wherein one endocyclic double bond may be present between any two consecutive ring positions or two alternating or nonalternating endocyclic double bonds may be present in the ring; nwherein n, n′, n‴, and n˝˝ are each independently 0, 1, or 2; nn˝ is 0, 1, 2, or 3; ny is 0 or 1; nx is 0 or 1; nA and B are each independently CH, CH₂, NR₇ wherein R₇ is hydrogen or R₇ is R₈CO wherein R₈ is alkyl of from one to ten carbon atoms, arylalkyl, aryl wherein the aryl or alkyl may be substituted by hydroxy, halogen, COOH, or CONHR₉ wherein R₉ is hydrogen or alkyl of from one to four carbon atoms and when A is NR₇, B can be O or S or when B is NR₇, A can be absent; n(CR₁₃R₁₄) n‴ wherein R₁₃ and R₁₄ are each independently hydrogen or lower alkyl; and nE is hydrogen, alkyl, OR₁₀ wherein R₁₀ is hydrogen or alkyl, NR₁₁R₁₂ wherein R₁₁ and R₁₂ are each independently hydrogen, lower alkyl, cycloalkyl alkylaryl, alkylheteroaryl, alkanoyl, amidine, peptide urethane, or R₁₁ and R₁₂ when taken together with the nitrogen to which they are attached form a ring of from three to six carbon atoms or |