| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9aaf1e3d2c6dcc92638559c30b7f2ca6 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-585
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-02 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2017-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43c2c8263ef5645ec11615fd14925b14 |
| publicationDate |
2019-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10449237-B1 |
| titleOfInvention |
Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
| abstract |
Bacterial strains are provided having at least one of a reduced size, a sialic acid coat, inducibly altered surface antigens, and expression of PD-L1 or CTLA-4 antagonists and/or tryptophanase. The bacteria may have improved serum half-life, increased penetration into tumors, increased tumor targeting and increased antitumor activity. The bacteria are useful for delivery of therapeutic agents that treat of neoplastic diseases including solid tumors and lymphomas. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11242528-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11633435-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11168326-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110951663-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10828356-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11779612-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021097144-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10729731-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11129906-B1 |
| priorityDate |
2014-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |