Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07d5f4667523063bce7464a42e3eb230 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e0daec85fdd4a4c04e22225e70a5cd9 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2535-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2531-113 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6809 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6881 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6876 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-6809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10 |
filingDate |
2015-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1fc8a2041439b265598d45ecbb0c691 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3370338b9d0a060b3d8a5cb0810e4957 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f465dab7a90669495ca2cc89cf9c3ec |
publicationDate |
2019-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-10392663-B2 |
titleOfInvention |
Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples |
abstract |
The invention is directed to methods for highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune heterodimers from a large number of biological samples containing lymphocytes of interest. Methods of the invention comprise performing a single pairing assay on a pool of source samples to determine nucleic acids encoding paired cognate receptor heterodimer chains in the combined pool. Separately, single-locus, high-throughput sequencing is performed on each individual sample to determine the plurality of sequences encoding one of the two receptor polypeptide chains. Pairs of cognate sequences determined in the pooled sample may then be mapped back to a single source sample by comparing the expression patterns of the single-locus sequences. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11131664-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11732302-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11248267-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954562-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10816543-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180813-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11002731-B2 |
priorityDate |
2014-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |