| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59e1d955a7b1560dc68cf7fd800e8fac |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-526
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2812 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2012-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2019-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ede7adcadd6021cabd2ce1b6249ded3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e65f50862c48d4aaec00394220ac78a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b012f8252b63b4dd712c030781d8054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af226973a2cded1df8049b2cdb9fa5d4 |
| publicationDate |
2019-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-10253100-B2 |
| titleOfInvention |
Therapeutic antigen-binding molecule with a FcRn-binding domain that promotes antigen clearance |
| abstract |
The present invention provides: a modified FcRn-binding domain having an enhanced affinity for the Fc Receptor neonatal (FcRn) at neutral pH; an antigen-binding molecule comprising said FcRn-binding domain, which has low immunogenicity, high stability and form only a few aggregates; a modified antigen-binding molecule having an increased FcRn-binding activity at neutral or acidic pH without an increased binding activity at neutral pH for a pre-existing anti-drug antibody; use of the antigen-binding molecules for improving antigen-binding molecule-mediated antigen uptake into cells; use of the antigen-binding molecules for reducing the plasma concentration of a specific antigen; use of the modified FcRn-binding domain for increasing the total number of antigens to which a single antigen-binding molecule can bind before its degradation; use of the modified FcRn-binding domain for improving pharmacokinetics of an antigen-binding molecule; methods for decreasing the binding activity for a pre-existing anti-drug antibody; and methods for producing said antigen-binding molecules. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10919953-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10618965-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11267878-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11053308-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11267877-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11718678-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11267868-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11643457-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11359009-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11584791-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11248053-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11046784-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11371039-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11608374-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11629185-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11359194-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11492393-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11780912-B2 |
| priorityDate |
2011-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |