| abstract |
1. Anti-IL-6 receptor antibody selected from the group consisting of:! (a) an antibody that contains a variable region of the heavy chain that contains CDR1, in which Ser at position 1 in the amino acid sequence of SEQ ID NO: 1 is replaced by another amino acid; ! (b) an antibody that contains a variable region of the heavy chain that contains CDR1, in which Trp at position 5 in the amino acid sequence of SEQ ID NO: 1 is replaced by another amino acid; ! (c) an antibody that contains a variable region of the heavy chain that contains CDR2, in which Tyr at position 1 in the amino acid sequence of SEQ ID NO: 2 is replaced by another amino acid; ! (d) an antibody that contains a variable region of the heavy chain that contains CDR2, in which Thr at position 8 in the amino acid sequence of SEQ ID NO: 2 is replaced by another amino acid; ! (e) an antibody that contains a variable region of the heavy chain that contains CDR2, in which Thr at position 9 in the amino acid sequence of SEQ ID NO: 2 is replaced by another amino acid; ! (f) an antibody that contains a variable region of the heavy chain that contains CDR3, in which Ser at position 1 in the amino acid sequence of SEQ ID NO: 3 is replaced by another amino acid; ! (g) an antibody that contains a variable region of the heavy chain that contains CDR3, in which Leu at position 2 in the amino acid sequence of SEQ ID NO: 3 is replaced by another amino acid; ! (h) an antibody that contains a variable region of the heavy chain that contains CDR3, in which Thr at position 5 in the amino acid sequence of SEQ ID NO: 3 is replaced by another amino acid; ! (i) an antibody that contains a variable region of the heavy chain, to |