| abstract |
PURPOSE: To obtain the titled compound useful as a raw material for antibiotic substances, etc., advantageously on an industrial scale, by treating a D,L-α-amino acid amide with e.g. a cultured liquid of a microbial strain belonging to Rhodococcus genus and capable of selectively hydrolyzing D-α-amino acid amide. n CONSTITUTION: A D,L-α-amino acid amide of formula [R is (substituted) lower alkyl, (substituted) phenyl, furyl, pyridyl, thiazolyl, imidazolyl or indolyl] (e.g. D,L-1-isopropyl-aminoacetamide) is treated with cultured liquid, living cell or treated cell of a microbial strain belonging to Rhodococcus genus and capable of selectively hydrolyzing D-α-amino acid amide (e.g. Rhodococcus erythropolis) to obtain the objective D-α-amino acid corresponding to the D,L-α-amino acid amide. n COPYRIGHT: (C)1988,JPO&Japio |