http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2011036135-A

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00
filingDate 2009-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1889e98c5b638e6795d053f16a4f1a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a7df6658db73821197a389f5564c713
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publicationDate 2011-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2011036135-A
titleOfInvention Method for producing optically active tert-leucine
abstract Provided is an industrially feasible method with excellent operability for producing optically active L- or D-tert-leucine which is important as a raw material for medicines and agricultural chemicals. A biocatalyst that stereoselectively hydrolyzes tert-leucine amide in an aqueous solution containing an acid radical is allowed to act on tert-leucine amide, and then a base is added to the reaction solution, followed by the solvent of the reaction solution. In the method of precipitating and separating the optically active tert-leucine produced by substituting the water with a poor solvent for optically active tert-leucine, the acetic acid radical is 45 mol% or more of the acid radicals in the solution used for solvent substitution. In addition, the poor solvent is an alcohol. [Selection figure] None
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