| abstract |
The present invention relates generally to the fields of pharmaceutical and cosmetics. More particularly, the present invention is a potent modulator (e.g., inhibitor) of androgen receptor, e.g., treatment such as dermatological diseases or disorders, sebaceous gland diseases or disorders, acne, seborrhea, Certain N- (pyrido) of formula (1) useful for the treatment of oily skin, seborrheic dermatitis, hirsutism or androgenetic hirsutism, atopic dermatitis, and androgenic alopecia, especially acne -4-yl) amide and N- (pyrimidin-4-yl) amide. The invention also includes compositions comprising the present compounds (e.g., pharmaceutical compositions, cosmetic compositions), methods of preparing the compositions, and androgen receptors using the compounds and / or compositions ( It also relates to methods (eg, inhibiting) and medical and / or cosmetic uses of the present compounds and compositions. |