| abstract |
The compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of androgen receptors in bone and / or muscle tissue and antagonize AR in male prostate or female uterus. Thus, these compounds, alone or in combination with other active agents, are useful for strengthening attenuated muscle tone, as well as osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, fractures Bone damage after osteoplasty, muscle loss, weakening, skin aging, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, poor regeneration Anemia and other hematopoietic diseases, inflammatory joints and joint repair, HIV ileus, prostate cancer, cancer cachexia, Alzheimer's disease, muscular dystrophy, cognitive impairment, decreased libido, premature ovarian dysfunction and autoimmune diseases It is useful in the treatment of conditions caused by androgen deficiency, including, or can be ameliorated by androgen administration. |