| abstract |
The present invention provides a new class of androgen receptor target substances (ARTA) that are selective androgen receptor modulators (SARMs). Some of the SARM compounds have been found to have unexpected androgenic activity and anabolic activity as non-steroidal ligands for the androgen receptor. Another SARM compound has been found to have unexpected antiandrogenic activity as a non-steroidal ligand for the androgen receptor. These SARM compounds are effective for the following (a) to (h), whether used alone or as a composition. (A) Male contraception. (B) Treatment of various hormone related diseases (eg, ADAM related diseases in older men). (C) Treatment of diseases related to ADIF. (D) Treatment and / or prevention of acute and / or chronic muscular atrophy. (E) Treatment and / or prevention of dry eye. (F) Oral androgen replacement therapy. (G) Reduction in the onset of prostate cancer, or cessation or regression of prostate cancer. (H) Promotion of apoptosis of cancer cells. |