| abstract |
NEW MATERIAL:The compound of formula I [R<1> is H, OH, lower alkoxy, lower alkanoyl, etc.; R<2> is H, lower alkyl, aralkyl, or di(lower alkyl)amino(lower alkyl); R<3> and R<4> are H, halogen, lower alkyl or alkyloxy; Z is O, S or H2; L is H, alkyl, tetrahydrofurfuryl, carbamoylalkyl, etc.; the dotted line in the formula II is single or double bond] and its acid addition salt. EXAMPLE:4-(2-Pyridylcarbamoyl)piperidine. USE:A medicine for circulatory organ. It has hypotensive and coronary and cere bral circulation improving activities. Dose: 5-500mg/kg daily in 1 - several divided doses. PREPARATION:The compound of formula I can be produced e.g. by reacting the compound of formula III with the compound of formula IV or its reactive derivative in an inert solvent under stirring and, if necessary, under heating. |