http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102004047776-B4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e0bf0928b608797b70bbc2b91c7e52e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-2417 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C11D3-38681 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C11D3-386 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-56 |
| filingDate | 2004-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2018-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac1cfba04de610da168c689e9a966ceb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c565d0b10116d0bdb46b15a444665f6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_780f97557222ad3b1a31d53ec3163a6f |
| publicationDate | 2018-05-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | DE-102004047776-B4 |
| titleOfInvention | Stabilized against di- and / or multimerization alpha-amylase variants, processes for their preparation and their use |
| abstract | Variant of the alpha-amylase from Bacillus sp. A 7-7 (DSM 12368) having at least one amino acid substitution with respect to the parent molecule, whereby at least one amino acid residue of the parent molecule exhibiting a neutral or positively polar or charged contribution to the electrostatic potential of the molecule located on the surface of the molecule becomes a more negative polar or negative charged amino acid residue has been exchanged, the following amino acid substitutions are possible: starting amino acid to Arg (R) K, Y, C, H, G, A, V, L, I, M, F, W, P, S, T, N, Q, E or D. Lys (K) Y, C, H, G, A, V, L, I, M, F, W, P, S, T, N, Q, E or D. Tyr (Y) C, H, G, A, V, L, I, M, F, W, P, S, T, N, Q, E or D. Cys (C) H, G, A, V, L, I, M, F, W, P, S, T, N, Q, E or D. His (H) G, A, V, L, I, M, F, W, P, S, T, N, Q, E or D. Gly (G) A, V, L, I, M, F, W, P, S, T, N, Q, E or D. Ala (A) V, L, I, M, F, W, P, S, T, N, Q, E or D. Val (V) L, I, M, F, W, P, S, T, N, Q, E or D. Lei (L) I, M, F, W, P, S, T, N, Q, E or D. Ile (I) M, F, W, P, S, T, N, Q, E or D. Met (M) F, W, P, S, T, N, Q, E or D. Phe (F) W, P, S, T, N, Q, E or D. Trp (W) P, S, T, N, Q, E or D. Pro (P) S, T, N, Q, E or D. Ser (S) T, N, Q, E or D Thr (T) N, Q, E or D. Asn (N) Q, E or D Gln (Q) E or D Glu (E) D and wherein said amino acid residue is in a position that belongs to one of the following two groups: (A) 5, 6, 7, 19, 22, 25, 26, 28, 29, 32, 33, 35, 37, 53, 72, 75, 76, 81, 82, 83, 84, 86, 87, 90 , 91, 93, 94, 95, 96, 98, 118, 136, 142, 149, 150, 151, 152, 154, 156, 158, 160, 171, 172, 181, 227, 229, 247, 251, 254 , 259, 260, 281, 283, 394, 395, 399, 400, 417, 418, 419, 420, 421 and 422; or (B) 435, 436, 439, 444, 445, 449, 450, 452, 458, 459, 460, 461, 463, 465, 466, 471, 473, 475, 476 and 484, each indicated in the count of the former Protein according to SEQ ID NO. 2, wherein the starting molecule is an alpha-amylase whose amino acid sequence is at least 96% identical to the amino acid sequence given in SEQ ID No.2 in positions +1 to 484, preferably 98%, more preferably 100% %. |
| priorityDate | 2004-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 999.