| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e5ae98e1f871b692e1873dbfafa0d38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8cd23dc36c6051a7715d8265066b9474
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_45b6e842af2ff4e7797752062b1f9bac
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e883b6c05893ba15e4a728146e79f05d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61F2-08
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S623-915 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3683
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3687
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61L27-3604 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-08 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-38
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61F2-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-36 |
| filingDate |
1998-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49fa741cf1dd917d7911e58cbb164ce5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c221c51aca1fa14192ce0eabf795acbf |
| publicationDate |
1999-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-9944533-A1 |
| titleOfInvention |
Soft tissue xenografts |
| abstract |
The invention provides an article of manufacture comprising a substantially non-immunogenic soft tissue xenograft for implantation into humans. The invention further provides methods for preparing a soft tissue xenograft by removing at least a portion of a soft tissue from a non-human animal to provide a xenograft; washing the xenograft in saline and alcohol; subjecting the xenograft to cellular disruption treatment; and either digesting the xenograft with a glycosidase or glycosidase digestion followed by treatment for sialylation. The invention also provides an article of manufacture produced by the above-identified method of the invention. The invention further provides a soft tissue xenograft for implantation into a human including a portion of a soft tissue from a non-human animal, wherein the portion has extracellular matrix and substantially only dead cells. The matrix and dead cells have substantially no surface α-galactosyl moieties and have sialic acid molecules linked to at least a portion of surface carbohydrate moieties. Each of the xenografts of the invention has substantially the same mechanical properties as a corresponding native soft tissue. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7261716-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102080371-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1651050-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4052735-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200019265-A
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10207025-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2545884-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102109309-B1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20140043733-A
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1156755-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1061866-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009050571-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8137411-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015035115-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20190116524-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11413373-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102263617-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9206442-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11406735-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11724004-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10874763-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1061866-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11110201-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105492034-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200008037-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102068071-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3549616-A1
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9211361-B2
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10814033-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2433492-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8324449-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1156755-A4 |
| priorityDate |
1998-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |