| abstract |
The present invention relates to compounds of formula (I) wherein: A is an optionally substituted ring system as defined herein; B is an optionally substituted 5- or 6-membered heteroaryl ring system or optionally substituted phenyl; D is an optionally substituted ring system as defined herein; X is of the formula -(CHR4)n- or -(CHR4)pCR?4=CR4(CHR4)¿q- wherein n is 1 to 3 and p and q are either both 0 or one of p and q is 1 and the other is 0; R1 is positioned on ring B in a 1,3 or 1,4 relationship with the -OCH(R3)- linking group in 6-membered rings and in a 1,3 relationship with the -OCH(R3)- linking group in 5-membered rings and is one of a variety or groups as defined herein; R3 is hydrogen or C¿1-4?alkyl; R?4¿ is hydrogen or C¿1-4?alkyl; and N-oxides thereof where chemically possible; and S-oxides of sulphur containing rings where chemically possible; a pharmaceutically acceptable salt and in vivo hydrolysable ester and amide thereof. The present invention also relates to processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them. |