| abstract |
Compounds of formula (I):n [in which: R 1 represents a saturated heterocyclic group attached to the bond or group represented by A through a ring carbon atom; R 2a , R 2b , R 2c , R 3a , R 3b , R 3c and R 3d are hydrogen or various other groups or atoms; and A represents a single bond or an alkylene group having from 1 to 6 carbon atoms] are serotonin 2 receptor antagonists and have the ability to inhibit the activity of squalene synthase. They can not only prevent and inhibit the development and progression of arteriosclerosis but can also inhibit thrombosis in arteriosclerotic lesions and can improve hemodynamics. |