| abstract |
A propionic acid derivative represented by general formula (I) or a pharmaceutically acceptable acid-addition salt thereof, wherein A represents OH, C1-C8 lower alkoxy, -NR1R2, or C1-C8 lower alkoxy which may be substituted by halogen, optionally susbtituted aryl, -COB or succinimido; R1 and R2 represent each H, C1-C8 lower alkyl or optionally substituted aralkyl, or alternatively R1 and R2 are combined together with the adjacent nitrogen atoms to represent a heterocycle; and B represents OH, C1-C8 lower alkyl, optionally susbtituted aryl, optionally substituted aryloxy, C1-C8 lower alkoxy, optionally substituted aralkyloxy, or NR1R2 wherein R1 and R2 are each as defined above. This compound is useful as a protease inhibitor. |