| abstract |
NEW MATERIAL:The compound of formula I [R 1 ) m is 2-methyl, 3-methyl, 2- methoxy, 4-fluoro, 3-chloro, 2-bromo, 4-carboxy, 4-nitro, etc.]. n EXAMPLE: p-Guanidinobenzoic acid 2,5-dichlorothiophenyl ester methanesulfonic acid salt. n USE: An elastase inhibitor useful as a remedy for pulmonary emphysema, atherosclerosis, nodose rheumatism, etc. n PREPARATION: The compound of formula I can be produced by reacting an acid addition salt of a compound of formula II (X is halogen) with a compound of formula III (R 2 is H, 1W4C alkyl, 1W4C alkoxy, halogen, etc.; n is 1W5) in the presence of a dehydrohalogenation agent (e.g. pyridine) at -5°CW room temperature. n COPYRIGHT: (C)1987,JPO&Japio |