| abstract |
PURPOSE: To obtain an antiretroviral agent containing guanidinobenzoic acid derivative as an active ingredient, having suppressive action an the proliferation of retrovirus with low toxicity and useful in prevention and treating disease of mammary animals including homo sapiens, especially of retrovirus-infected homo sapiens. n CONSTITUTION: The objective agent contains a guanidinobenzoic acid derivative [e.g. a compound expressed by formula I (R is phenyl, naphthyl, etc.) and salt thereof, etc.] as the active ingredient. Especially, the compounds expressed by formula II (Z a is single bond, CH 2 , CH 2 CH 2 , etc.; R a1 and R a2 are H, 1 to 10C alkyl, 3 to 8C cycloalkyl. etc.) or the compounds expressed by formula III (Z b is single bond, CH 2 , etc.; R b is H or lower alkyl), etc., or the nontoxic acid salts (e.g. hydrochloride or hydrobromide salt can preferably be used. n COPYRIGHT: (C)1990,JPO&Japio |