| abstract |
The purpose of the present disclosure is to provide anti-CD137 antigen-binding molecules that have an effect of activating immunocytes, a cytotoxic activity or an antitumor activity and yet scarcely affect non-tumor tissues such as normal tissues and have few side effects, and a method for using these molecules. By finding a CD137 antigen-binding molecule that shows a change in CD137-binding activity depending on various substances (for example, a low molecular compound) in a target tissue and producing the molecule, provided is an anti-CD137 antigen-binding molecule that has an effect of activating immunocytes, a cytotoxic activity or an antitumor activity and yet scarcely affects non-tumor tissues such as normal tissues and has few side effects. Also provided are a method for using the anti-CD137 antigen-binding molecule, a pharmaceutical formulation, etc. The present disclosure also provides an antigen-binding molecule showing a change in antigen-binding activity depending on a low molecular compound, a method for producing the molecule and utilization of the same. |