abstract |
A compound represented by formula (I) and having a property of modulating the activity of an androgen receptor, or a pharmaceutically acceptable salt of the compound. X represents S or O; Z represents (R a ) n -A-(CR 13 R 14 ) 0-1 -(CR 11 R 12 ) 0-1 -; A represents an aryl group or a heteroaryl group; R 1 represents an alkyl group, a cycloalkyl group, an alkenyl group, an alkynyl group, an alkoxyalkyl group, an aryl group, an arylalkyl group, a heterocyclic group or a heterocyclic alkyl group; R 2 represents a hydrogen atom, a halogen atom, an alkyl group, a cycloalkyl group or a phenyl group; R 3 represents a hydrogen atom, a halogen atom, an alkyl group, a cycloalkyl group, an alkoxyalkyl group, an alkenyl group, an alkynyl group, a cycloalkenyl group, an aryl group, an arylalkyl group, a heterocyclic group, a heterocyclic alkyl group, an acyl group, a cycloalkylcarbonyl group, a benzoyl group, a spiroalkyl group, an adamantyl group, a silyl group or R 31 R 32 NCO-; and R 4 and R 5 independently represent a hydrogen atom, a halogen atom, an alkyl group, a phenyl group or a cycloalkyl group. |