| abstract |
(57) [Summary] (Modified) [PROBLEMS] To provide a compound for a pharmaceutical composition effective in alleviating pain. The compound is a novel aromatic compound represented by the general formula (XXI). [In the formula, X represents CH or N; R 1 represents a hydrogen atom or a bromine atom; R 2 represents n-propyl, 2-hydroxyethyl or 3-pyridylmethyl] [Effect] of the formula (XXI) The compounds are antagonists of the E-type prostaglandin pain-enhancing effects and are important for alleviating the pain associated with inflammatory conditions such as rheumatoid arthritis and osteoarthritis. |