abstract |
Disclosed are methods of treating stearoyl-CoA desaturase (SCD) mediated diseases or conditions in mammals, preferably humans. This method comprises administering to a mammal in need thereof a compound of formula (I) wherein V, W, R 1 , R 2 , R 3 , and R 4 are defined herein. Including the steps of: Also disclosed are pharmaceutical compositions comprising the compound of formula (I). This disease or condition is metabolic syndrome, syndrome X, diabetes, insulin resistance, impaired glucose tolerance, non-insulin dependent diabetes, type II diabetes, type I diabetes, diabetic complications, weight disorder, weight loss, body mass index Or a disease associated with leptin. |