| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82720f0fe09c6d788db8fde9be2350dc |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2710-10333
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-03
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-033
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2803
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70503
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-7051
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70521
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-03048
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-3084
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate |
2016-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_395c1185db14d48eb7c7ae53bda95765
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e741084946bafe5703cb957605b5416 |
| publicationDate |
2016-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2016174407-A1 |
| titleOfInvention |
Nucleic acid construct for expressing more than one chimeric antigen receptor |
| abstract |
The present invention provides a nucleic acid construct comprising the following structure: A – X – B in which X is a nucleic acid sequence which encodes a cleavage site; and A and B are nucleic acid sequences encoding a first and a second chimeric antigen receptor (CAR), each CAR comprising: (i) an antigen-binding domain; (ii) a spacer (iii) a trans-membrane domain; and (iv) an endodomain wherein the antigen binding domains of the first and second CARs bind to different antigens; wherein one of the first or second CARs is an activating CAR comprising an activating endodomain and the other CAR is an inhibitory CAR comprising a ligation-off inhibitory endodomain; and wherein: (a) the first and/or second CAR comprises an intracellular retention signal; and/or (b) the signal peptide of the first or second CAR comprises one or more mutation(s) such that it has fewer hydrophobic amino acids. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021069915-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10829737-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11253547-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110621694-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10836999-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018211246-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018211244-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10538739-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774309-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11560548-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018096361-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018209052-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019197819-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11365236-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7161940-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11274141-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774311-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2018265258-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4021465-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10428305-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11154575-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IL-263979-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/IL-263979-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10801012-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111954813-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11141436-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020519230-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020120965-A1 |
| priorityDate |
2015-04-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |