| abstract |
The present invention relates to bicyclic himbacine derivatives of the formula or a pharmaceutically acceptable salt thereof wherein: R1 is halo; -CN; alkyi; cycloalkyi; alkoxy; phenyl, which is optionally substituted one or twice independently by alkyi, halo, or -CN; or a thiophene ring, which is optionally substituted once or twice independently by alkyi. The compounds of the invention are effective inhibitors of the PAR-I receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ASC, secondary prevention of myocardial infarction or stroke, or PAD. |