| abstract |
Substituted bicyclic and tricyclic modified himbacine derivative of the formula: n nor a pharmaceutically acceptable salt or solvate of said compound wherein represents an optional double bond and wherein E n , F n , G n , Z n , J n , X, R 3 , R 9 , R 10 , R 11 , R 32 , R 33 , B and Het are herein defined are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other agents is also claimed. |