abstract |
The present invention relates to bicyclic himbacine derivatives of the formula, stnjctrually represented, or a pharmaceutically acceptable salt thereof wherein: R1 is any of the recited compounds, W is any of the recited compounds and the remaining variables are described herein. The compounds of the invention are effective inhibitors of the PAR-1 receptor. The inventive compounds may be used for the treatment or prophylaxis of disease states such as ASC, secondary prevention of myocardial infarction or stroke, or PAD. |