| abstract |
A compound represented by the structural formula n n n n n n n n n n n n and pharmaceutically acceptable salts and solvents thereof is disclosed, wherein:n the single-dashed line n n n n n n n n n n n n n n n n n n n between the ring carbons to which R 10 and R 34 are attached represents either a single bond or a double bond; n the double-dashed line n n n n n n n n n n n n n n n n n n n n between X and the carbon to which Y is attached represents either a single bond or an absent bond; n X is —O— or —NR 6 — when the double-dashed line represents a single bond; X is H, —OH or —NHR 20 when the double-dashed line represents an absent bond; n and other parameters are as defined herein. n n n n n n n Also disclosed are pharmaceutical compositions and combinations containing said compounds and their uses as thrombin receptor antagonists and binders to cannabinoid receptors. |