| abstract |
The present invention relates to functionalized ploy(2-oxazoline) polymers, which are very suitable as a carrier and/or delivery vehicle (conjugate) of drugs, such as small therapeutic molecules and bio-pharmaceuticals. These polymers are characterized in that they comprise repeating units that are represented by the following formula -[N(R 1 )-(CHR 2 )m]- wherein R 1 is R 3 -(CHR 4 )n-CONH-R 5 ; R 2 is selectd from H and optionally substituted C 1-5 alkyl; R 3 is CH 2 CO, C(O)O, C(O)NH OR C(S)NH; R 4 is selected from H and optionally substituted C 1-5 alkyl; R 5 is H; an C 1-5 alkyl; aryl; or a moiety comprising a functional group that can be used for conjugation; m is 2 or 3 and n is 1-5; or n is 0 and R 3 is CH 2 . The invention relates further to a conjugate of these polyoxazoline polymers with at least one active moiety, such as a therapeutic moiety, a targeting moiety and/or diagnostic moiety, and to the use of these conjugates in the therapeutic treatment or prophylactic treatment or diagnosis of a disease or disorder. |