| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e40d73555b988e4cb5b6af42895d8aab
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81ad53b64eb74859acdc01278829b080
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dad5a6969d9c5113e87638a276760926 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9121 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5041 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-542 |
| filingDate |
2012-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4b0e069eaf4ccabe7f641e04c83c20c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dfa1368a9575489e37843c665ec649d |
| publicationDate |
2013-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2013033623-A1 |
| titleOfInvention |
Profiling of signal pathway proteins to determine therapeutic efficacy |
| abstract |
The present invention provides methods for detecting, measuring and quantitating the activation states of components of the PI3K signaling pathway in cells such as tumor cells and selecting an anticancer therapy therewith. The methods involve a collaborative enzyme enhanced reactive-immunoassay (CEER) in which first activation state-independent antibodies specific for one member of a dimerised receptor tyrosine kinase (RTK) pair or a PI3K p110 subunit are labeled with a facilitating moiety (e.g. glucose oxidase) and second activation state-independent or dependent antibodies specific for the other member of the RTK pair or PI3K p85 or PI3K p110 subunit labeled with a signal amplification moiety (e.g. HRP). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105378481-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018505138-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10571467-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014122600-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109789204-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014122582-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016000966-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11333659-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11073509-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9688761-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3640645-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016063204-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10273308-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11160863-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11435347-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11162943-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10976307-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3217179-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017210214-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015110989-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10184006-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015083085-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015028974-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015003945-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10273304-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018220588-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3807640-A4 |
| priorityDate |
2011-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |