| abstract |
Provided herein are methods and compositions for treating or preventing a hedgehog-associated cancer (e.g., a hedgehog ligand-dependent cancer cell growth chosen from a neuroendocrine cancer, a sarcoma (e.g., a musculoskeletal sarcoma, such as chondrosarcoma and osteosarcoma)), a head and neck cancer, or a lung cancer by administering to a subject a hedgehog inhibitor, alone or combination with another anticancer agent (e.g., paclitaxel or a paclitaxel agent, a tyrosine kinase inhibitor (e.g., receptor tyrosine kinase (RTK) inhibitor) or an mTOR inhibitor). |