| abstract |
The present invention provides a method for the treatment or prevention of conditions which can be ameliorated by Smo antagonism, which method comprises administration to a patient in need thereof of an effective amount of a compound of formula I or a composition comprising a compound of formula I: n n n n n n n n n n or a pharmaceutically acceptable salt or solvate thereof; wherein:n 2 of X, Y and Z represent nitrogen atoms, and the other represents an oxygen atom; R 1 and R 2 are taken together with the atom to which they are attached and represent a cyclobutyl ring, optionally substituted with 1-2 fluorine atoms, and R 3 represents hydrogen or a fluorine atom; or R 1 represents methyl, R 2 represents methyl or a fluorine atom and R 3 represents a fluorine atom. |