| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b88d52380c9cc2872b5e3ab3663dda1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e17711d5dbfe4a269f737fb0bc15eabe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_671f66016a66b2a74bd3b52b51cc90db
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9cdbc4cfa78c1c4c9edba21daaed34a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-91011 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6816
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6827
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-28
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48 |
| filingDate |
2010-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e1107e1973dbdf2b74410f33522463b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf39d8a5d860b27cbe4d080c2b59a36a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cb9bcc13490f7ea9cb202504a4aa111 |
| publicationDate |
2010-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2010115847-A1 |
| titleOfInvention |
Conversion of alpha-hydroxyalkylated residues in biomolecules using methyltransferases |
| abstract |
The present invention relates to targeted conversion of alpha-hydroxyalkylated residues in biomolecules in the presence of a directing methyltransferase, namely to targeted removal of the alpha-hydroxyalkyl moieties to give unmodified residues, or targeted derivatization of the alpha-hydroxyalkyl groups by covalent coupling of non-cofactor compounds represented by formula HQ-LX1 wherein X represents a functional group or a reporter group attached via a linker moiety L, and QH is selected from HS-, HSe-, HO-H 2 N-, HN 3 or HCN in the presence of a directing methyltransferase. Further development of the method of targeted conversion comprises methods for targeted labeling a biomolecule and method for detecting hydroxymethylated target sites in a biomolecule according to the present invention. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9347093-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7314289-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8822146-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2013072515-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2594651-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2022519116-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9988673-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8889352-B2 |
| priorityDate |
2009-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |