| abstract |
A compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof: wherein X is an oxygen or sulphur atom A is CH(R6)-, -O- or NR7 or when A is NR7, then R1 and NR7 can together form a ring such that R1 and R7 are (CH2)n, where n is 2-4, preferably 2-3; Y is a bond, CH(R6)-, -O- or NR7 or A and Y together form a single bond between the aromatic group and the carbonyl group but when A is-O- then Y is not -O-; R1 and R2 are independently hydrogen, halogen, OR8, NR9R10, NR9COR11, NR9SO2R11 or C1-6 alkyl optionally substituted by fluorine, hydroxyl, C1-6 alkoxy or NR9R10; R3 is C1-6 alkyl, C3-8 cycloalkyl C4-10 alkylcycloalkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR9R10; R4 is hydrogen, halogen, CF3, OR9, NR9R10, NR9COR11, NR9SO2R11 or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR9R10; R5 is hydrogen, halogen, CF3, OR8, COOR9, CONR9R10 or SO2R11; The compounds find use in the treatment of amyloid related diseases, such as Alzheimer disease. |