http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108794427-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-135 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D285-135 |
| filingDate | 2018-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108794427-B |
| titleOfInvention | A kind of synthetic method of 1,3,4-thiadiazole derivatives |
| abstract | The invention discloses a method for synthesizing 1,3,4-thiadiazole derivatives, comprising: (1) using hydrazine hydrate as a raw material, and reacting with an acid under the action of a catalyst to obtain a hydrazide compound I; (2) using hydrazine hydrate as a raw material; Alkyl chloroformate and thiocyanate react under solvent conditions to obtain isothiocyanate compound II; (3) in the reaction system of isothiocyanate compound II, add a solution containing compound I to react to obtain The solution containing compound III; (4) the solution of compound III is dehydrated, neutralized and washed with water to obtain compound IV; (5) compound IV is added with halogenated alkyl or sulfuric acid diester under the condition of acid binding agent and solvent to react to obtain compound V ; (6) Compound V is aminated with primary amine to obtain 1,3,4-thiadiazole derivative VI. The preparation method of the invention has the advantages of green and pollution-free, simple and convenient operation, high yield, mild reaction conditions and the like. |
| priorityDate | 2018-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 98.