| abstract |
Disclosed is a novel 1,2-dihydroquinoline derivative represented by the general formula (1) below, which has a substituted phenylchalcogeno lower alkyl group and a phenyl group having an ester structure introduced therein as substituents, or a salt of such a derivative. The compound (1) or a salt thereof is useful as a glucocorticoid receptor modulator. In the formula below, R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a lower alkyl group; R3 and R4 may be the same or different and represent a hydrogen atom or a lower alkyl group; R5 represents a hydrogen atom or a lower alkyl group; R6 represents a halogen atom, a lower alkyl group, a hydroxy group, a lower alkoxy group or a nitro group; X represents -C(O)-, -C(O)NR8-, -S(O)2- or the like; R7 and/or R8 may be the same or different and represent a hydrogen atom, an optionally substituted lower alkyl group, an optionally substituted aryl group, an optionally substituted heterocyclic group, an optionally substituted lower alkoxy group or the like; Y represents a lower alkylene group; Z represent a chalcogen atom; and p represents 0, 1, 2 or 3. |