| abstract |
The present invention relates to containing 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivatives with substituting oxygen, i.e. the glucocorticoid of the compound represented by formula (1) or its salt Receptor agonists, and novel pharmacological effects of the agonists. In the formula, R 1 represents formula (2a), (3a), (4a) or (5a), R 2 represents -(CO)-R 8 , -(CO)O-R 9 etc., R 2 -O-in The 4 or 5 position of the benzene ring A is substituted, R 3 represents a lower alkyl group, R 4 , R 5 , R 6 or R 7 represents a halogen atom, a lower alkyl group that may have a substituent, etc., m, n, p or q represent 0, 1, etc., R 8 , R 9 , etc. represent a lower alkyl group, a lower alkenyl group, etc. which may have a substituent. |