| abstract |
Disclosed is a glucocorticoid receptor agonist composed of a compound represented by formula (1) or a salt thereof, which is a 2,2,4-trimethyl-6-phenyl-1,2-dihydroquinoline derivative having a substituted oxy group. A novel pharmacological action of the agonist is also disclosed. In the formula, R 1 represents a group represented by formula (2a), (3a), (4a) or (5a); R 2 represents -(CO)-R 8 , -(CO)O-R 9 or the like; R 2 -O- is substituted at the 4-position or the 5-position of the benzene ring A; R 3 represents a lower alkyl group; R 4 , R 5 , R 6 or R 7 represents a halogen atom, an optionally substituted lower alkyl group or the like; m, n, p or q represents 0, 1 or the like; and R 8 , R 9 or the like represents an optionally substituted lower alkyl group, a lower alkenyl group or the like. |