| abstract |
Provided herein are methods for identifying agents that modulate the activity of sirtuin ADP ribosyltransferases, e.g., Sirt4 and Sirt6. Also provided are methods for treating a hyperproliferating disease, comprising, e.g., administering to a subject in need thereof an agent that reduces the activity or protein level of an ADP ribosyltransferase, e.g., Sirt6. |