http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2007086076-A3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21cdd6c9aa2a56078633fd99c1537ae http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a466df98591825faa92287cf626fa3ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_32014a17f91ef3dadd6638038d20187e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2cab09b623a24f8b6748a691e36f4499 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55e46d7a8367cfe37357ed304c84f782 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D261-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D261-18 |
| filingDate | 2006-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d507f732f50dd93af081d487bec2ed0d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b14a5b563aa8dd15b2fc11c4adae1f7b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b7a9bcc7c5c3353d88e18679c9ccafef http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff735b76cd2ba82f18470f9dd1a59c03 |
| publicationDate | 2009-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2007086076-A3 |
| titleOfInvention | An improved process for preparation of leflunomide |
| abstract | This invention describes a process for the preparation of N-(4-trifluoromethyl)-5-methylisoxazole-4-carboxamide commonly known as leflunomide comprising : (a) reacting ethylaceto acetate, triethylorthoformate, and acetic anhydride with simultaneous distillation to form ethyl ethoxymethyleneacetoacetic ester; (b) reacting the ethyl ethoxymethyleneacetoacetic ester with aqueous hydroxylamine without using any external base and without any distillation to form ethyl-5-methylisoxazole-4-carboxylate; (c) reacting the ethyl-5-methylisoxazole-4-carboxylate with strong acid to form -5-methylisoxazole-4-carboxylic acid; (d) 5-methylisoxazole-4-carboxylic acid is reacted with thionyl chloride in presence of N, N-Dimethylformamide and equimolar of 4-trifluoromethylaniline without any external base to obtain highly pure Leflunomide. |
| priorityDate | 2006-01-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.