abstract |
As a result of examining an inhibitory effect of an anti-IL-6 receptor antibody on the cytotoxic T cell induction, a mouse treated with the anti-IL-6 receptor antibody showed a statistically significant decrease in CTL activity against an alloantigen compared with an antibody-untreated mouse or a mouse treated with a control antibody. Further, as a result of administering an anti-IL-6 receptor antibody to a recipient of an allogeneic mouse model of heart transplantation, the infiltration of an inflammatory cell to the transplanted heart was histopathologically inhibited and a graft survival of transplanted heart was significantly prolonged. That is, the inventors found for the first time that the induction of cytotoxic T cell is inhibited by administering the anti-IL-6 receptor antibody and acute rejection response after transplantation can be inhibited. |