| abstract |
The present disclosure provides drug-ligand conjugates that are potent cytotoxins, wherein the drug is linked to the ligand through either a peptidyl, hydrazine or disulfide self-immolative linker. In a particular embodiment the cytotoxin is represented by duocarmycins and derivatives thereof. The disclosure is also directed to compositions containing the drug-ligand conjugates, and to methods of treatment using them. |