| abstract |
The present invention relates to a new class of alkylating agents comprising a thieno-indole moiety linked to a DNA-binding moiety, which have cytotoxic activity and are useful in the treatment of diseases such as cancer, cell proliferative disorders and viral infections. The present invention also provides methods for preparing these compounds, pharmaceutical compositions containing them and methods for treating diseases with such compounds or pharmaceutical compositions containing them. The present invention also relates to the use of this new class of alkylating agents in the preparation of conjugates. |