| abstract |
The present invention provides hydrophobic heparin conjugates which are soluble not in water but in organic solvents, a preparing method and a use thereof. Particularly, the present invention provides the heydrophobic heparin conjugates which are prepared by covalently binding polymer and hydrophobic materials to heparin. The hydrophobic heparin conjugates of the present invention maintain a good antithrombogeic effect and are insoluble in water by their hydrophobicity, so they can be effectively used for coating agents to modify the surface of medical devices. |