| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d40a185e47b2af2ccdab8dca479cb6b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4ed14163989d522b63aab2eb59cbcc7a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ddab3251d918ca11869be71783f2332 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-0058
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-475
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2001-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f0fe38557db6fa7f482c07e4e624a362 |
| publicationDate |
2002-02-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-0210368-A1 |
| titleOfInvention |
Tumor-specific promoters |
| abstract |
A DNA comprising a 609 bp base sequence ranging from the 559- to +50-positions (referring the top base sequence of the exon 1 as to +1) of the gene of midkine which is a human retinoic acid-responsive growth/differentiation factor; and a DNA comprising a 251 bp base sequence ranging from the 213 to +38-positions (referring the transcriptional initiation point as to +1) of the c-erbB-2 gene belonging to the EGF receptor family and having a tyrosine kinase activity. Because of carrying tumor-specific transcriptional activity and having high promoter activity, these DNAs are highly useful as tumor-specific promoters which are used in suicide gene therapy by the combined use of a drug metabolic enzyme gene with a prodrug for treating cancer which can be activated by the above-described enzyme, gene therapy for cancer with the use of an expression vector containing a gene encoding a cytokine, gene therapy for cancer with the use of an oncolytic virus showing a cytotoxic effect on tumor cells, etc. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-4913126-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8916378-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8846401-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2008519596-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8835398-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014504871-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2012010710-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009529855-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2476596-C1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8859745-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8859747-B2 |
| priorityDate |
2000-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |