abstract |
The present invention provides a nucleic acid construct that can be used to control angiogenesis in a specific cell region of a subject. A nucleic acid construct comprising an isolated polynucleotide consisting of a conditionally replicating adenovirus transcriptionally linked to a preproendothelin-1 promoter, wherein the promoter comprises the adeno in angiogenic endothelial cells. Selectively direct viral transcription. The promoter is a PPE-1-3x promoter, and the isolated polynucleotide comprises a specific sequence. [Selection figure] None |