| abstract |
The invention concerns the field of biology, genetics and medicine. In particular, it concerns novel methods for detecting, characterising and/or treating (or managing) degenerative diseases of the motor neurons, in particular amyotrophic lateral sclerosis. The invention also concerns methods for identifying or screening compounds active in said pathologies. The invention further concerns compounds, genes, cells, plasmids or compositions useful for implementing said methods. The invention finally concerns the part played by calcineurin in said pathologies and its use as therapeutic, diagnostic or experimental target. |